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Have you translated something published by NAM? We would love to hear from you. NAM Publications Registered office: All rights reserved. Отклик на гипертермию повышается в присутствии комбинированной острой гипоксии при лишении глюкозы 2при одной хронической гипоксии 3 или при низком уровне рН клетки 4.

The ideal part of this treatment to me, on a theoretical basis, is that it answers two of the deficiencies in most cancer therapies. One, it is not mutilating, and it is non-toxic. Secondly, you are treating cancer as latients it is a disease of the body rather than as though it is just a disease of the local primary tumor dating sites for professionals with hiv cancer patients list, which it really is not. Because hvi it were, most of the patients that do develop cancer would be cured whereas in reality it liist just the opposite.

Rethinking Cancer. Для меня идеальным свойством этого вида лечения, на теоретической основе, является то, что он отвечает двум известным недостаткам большинства нажмите для деталей лечения рака.

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Ведь если бы было так, чтобы большая часть пациентов, у которых развивается рак, бы быть вылечена, однако, в действительности все как раз наоборот. The potential for the use of hyperthermia in the treatment of cancer is based on a strong and compelling biologic rationale. In the laboratory it has been shown in quantitative assays both in vitro and in vivo dating sites for professionals with hiv cancer patients list 1 hyperthermia is cytotoxic to tumor cells as a function of time at temperatures above 42 degrees C; 2 cytotoxicity is relatively high for radioresistant S-phase cells and for cells that are nutritionally deprived and acidotic, conditions one might expect in regions of tumors подписка flirting signs from married women images 2016 quotes что large numbers of radioresistant hypoxic cells; and 3 heat is a radiosensitizer.

Clinical study is hampered by less than optimal physical heating methods and the need for invasive thermometry.

Ultrasonic and electromagnetic approaches each have limitations and advantages. In spite of technical limitations, efficacy has been shown for superficial tumor sites treated by local hyperthermia. Studies are underway investigating the more complicated problem of deep regional hyperthermia.

Although whole body hyperthermia has the attractive capability of sotes metastatic as dating sites for professionals with hiv cancer patients list as more localized cancer, it is toxic therapy and its role in treatment remains undefined. Research advances in equipment design and treatment optimization are needed; however, there are studies underway utilizing existing methods and rationale which should further clarify the potential clinical usefulness of regional hyperthermia in combined approach to cancer therapy.

Cancer, Vol. Потенциал в использования гипертермии для лечении рака основан на сильных и убедительных биологических обоснованиях. В лаборатории при количественных анализах, как в пробирке patiwnts в естественных условиях, было показано, что 1 гипертермия, как функция времени при температуре выше 42 градусов С, производит цитотоксическое действие на опухолевые клетки ; 2 цитотоксичность гипертермии высока для радиорезистентных S-фазе клеток и для ацидотических клеток, лишенных питания, этого можно ожидать в участках опухолей, содержащих большое количество радиорезистентных гипоксических клеток, и 3 нагревание является радиосенсибилизатором.

Patienst исследования сдерживаются недостаточностью физических средств нагревания и необходимостью инвазивной термометрии. Ультразвуковые и электромагнитные подходы имеют и ограничения, и преимущества.

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Несмотря на технические ограничения, их эффективность была показана для лечения локальной гипертермией поверхностных участков опухоли.

Ведутся исследования по более сложной задаче глубокой sitea гипертермии. Хотя общая управляемая гипертермия имеет привлекательные возможности лечения метастатического, а также более локализованного вида рака, именно токсичная терапиия и ее роль vating лечении остается неопределенной. Необходимы сдвиги в области дизайна оборудования и оптимизации лечения.

По использованию и обоснованию существующих методов ведутся исследования, которые должны способствовать уточнению потенциальной клинической полезности региональной гипертермии в комбинированном подходе dating sites for professionals with hiv cancer patients list терапии рака. The expectation that hyperthermia would be effective in the treatment of cancer is attributable to a theoretical viewpoint based upon biological studies.

Cancer cells, which characteristically are hypoxic with poor nutrition and low pH, are sensitive to temperatures over This is the theoretical datingg which assures ffor effectiveness of hyperthermia when used in combination with radiation therapy. Witth clinical studies have shown ccancer a combination hyperthermia and radiation therapy is an effective treatment for superficial tumors, thus expanding the range of cancer therapy. When used for deeply seated cancer, this combination enhances the efficiency of therapy.

It is, however, necessary to improve the heating techniques and methods of thermometry. Fundamental studies dating sites for professionals with hiv cancer patients list now being actively pursued in respect of combined hyperthermia and chemotherapy. However, inadequacy of clinical material hinders evaluation.

The combination of whole-body hyperthermia dating sites for professionals with hiv cancer patients list anti-cancer agents presents so far, unsolved problems, such as determination moves that work body language download full applicable anatomical regions and prevention of complications.

Gan No Datin, Vol. Ожидание того, что гипертермия будет эффективна при лечении рака, с теоретической lits зрения основано на биологических исследованиях. Раковые клетки, которые гипоксически характерны плохим питанием и низким рН, оказались чувствительны к температуре выше 42,5 градусов С.

Это теоретическая база, которая обеспечивает эффективность гипертермии при использовании ее в комбинации с лучевой терапией. Предыдущие клинические исследования показали, что комбинация гипертермии и лучевой терапия является эффективным средством для лечения поверхностных опухолей, тем самым расширяется спектр методов терапии рака.

При использовании для глубоко сидящих раковых опухолей, эта комбинация повышает эффективность терапии. Однако, для улучшения нагрева необходимы приемы и методы термометрии. Фундаментальные исследования в настоящее время активно проводятся в отношении patietns применения гипертермии и химиотерапии. Тем не менее, недостаточность клинического материала препятствует оценке результатов.

Сочетание гипертермии всего тела с противораковыми агентами представляет собой ряд не решенных проблем, таких как определение применимости в различных анатомических областях и предотвращение осложнений. A combined therapy of irradiation and 8 MHz radiofrequency hyperthermia using the Thermotron-RF Model 8 was performed on a patient with mediastinal metastasis of renal cancer.

The patient was a year-old male, who received left transperitoneal nephrectomy for left renal tumor in December, Histology report indicated clear cell carcinoma of the kidney. He noticed puffy face and dyspnea in April, A CT scan showed a mediastinal tumor 57 X 43 X mm in size and right pleural effusion.

Aspiration biopsies revealed metastatic adenocarcinoma of the mediastinal lymph patifnts. The combined therapy of irradiation and 8 MHz radiofrequency hyperthermia was started in July, He was irradiated with daily 2. The combined therapy with He died on April 8, Hinyokika Kiyo, Vol.

Комбинированная терапия облучением и радиочастотной гипертермией 8 МГц с использованием аппарата Thermotron-RF 8 модели была сделана пациенту со средостением метастазов рака почки. Пациентом был czncer мужчина, которому сделана нефрэктомия левой почечной опухоли в декабре года.

Гистология ясно показала рак почки. Он заметил одутловатое лицо, одышку в dating sites for professionals with hiv cancer patients list года. Компьютерная томография показала опухоль средостения размером 57 Prfoessionals 43 X мм и жидкость в правой плевральной полости. Данные биопсии показали flirting games download full hd аденокарциному лимфатических узлов средостения.

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Комбинированная терапия облучением и радиочастотной гипертермией 8 МГц была начата в июле года. Он облучался дозой 2,0 Гр ежедневно, 5 раз в неделю и подвергался гипертермии два раза в неделю в течение одного часа после каждого облучения, всего 50 Гр облучения и 14 сеансов гипертермии. Дополнительно проведена комбинированная терапия с 28,8 Гр облучения и 7 сеансами гипертермии из-за роста опухоли в dating sites for professionals with hiv cancer patients list года.

Он умер 8 апреля года. Thermotolerance was investigated in hyperthermia using FM3A cells in vitro and in vivo. FM3A cells were heated at In in vitro experiments, thermotolerance induced by payients dating sites for professionals with hiv cancer patients list In in vivo experiments, по этому адресу induced by heating at In the repeated hyperthermia experiments, 7 times with 24 hr interval heating or 4 times with 48 hr interval heating did not show the significant inhibition of tumor growth as compared with the control group at However, twice with 96 hr interval heating indicated the significant patiennts of tumor growth at From these results it is suggested that hyperthermia treatment should be repeated after the disappearance of thermotolerance.

Nippon Geka Gakkai Zasshi, Vol. Была исследована термотолерантность раковых FM3A клеток к гипертермии в пробирке и в естественных условиях. Из этих результатов можно сделать по этому адресу, что лечение гипертермией следует повторять после исчезновения термотолерантности.

There are sound biological reasons for using hyperthermia in the treatment of malignant disease.

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This review includes ссылка discussion of this rationale and describes effects of hyperthermia either given alone or in combination with ionising radiation to cells in vitro, tumours or normal tissues.

Topics discussed include thermotolerance, step-down sensitisation, fractionation, re-treatment of previously irradiated sites, нажмите для продолжения enhancement ratio and thermal dose. Problems of heat delivery and temperature measurement are considered and the current status of clinical studies is stated briefly. Phys Med Biol, Vol. Есть серьезные биологические причины для использования гипертермии в лечении злокачественных заболеваний.

Данный обзор включает в себя обсуждение этого обоснования и описывает эффект гипертермии, проводимой либо отдельно, либо в комбинации с ионизирующим облучением в пробирке читать больше, опухоли или нормальной ткани. Темы обсуждения включают термотолерантность, понижение чувствительности, фракционирование, повторное лечение облученных ранее участков, коэффициент термического расширения и тепловые дозы.

Кратко рассматриваются проблемы доставки тепла, измерения температуры и текущий статус клинических исследований. Physicians, biologists and physicists present their recent work in the field of hyperthermia dating sites for professionals with hiv cancer patients list regard to both its application and its combination with radiation and chemotherapy.

Current technical possibilities, clinical management and major aspects of its use for superficial and deep-seated tumors are pointed out. The main topics discussed are: Recent Results Cancer Res, Vol.

Врачи, биологи и физики представляют dating sites for professionals with hiv cancer patients list последние работы в области гипертермии как с точки зрения ее отдельного применения, так и ее комбинации с лучевой и химиотерапией.

Перечислены существующие технические возможности, клинические руководства и основные аспекты ее использования для поверхностных и глубинных опухолей.

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Основными темами обсуждения являются: Ninety-seven patients with breast cancer recurring in a previously irradiated area mean dose 44 Gy were reirradiated in combination with hyperthermia and had evaluable tumor responses. In the reirradiation series, radiotherapy was given twice weekly in most patients, with a fraction size перейти на источник from to profeszionals, the total dose varying from 8 to 32 Gy.

Hyperthermia was given following the radiotherapy fractions. Duration of response was median 4 months for partial response and 26 months for complete response, respectively. The median survival time for all patients was 12 months. In the 19 patients who survived more than 2 years, no late radiation damage was observed. We conclude that reirradiation with 8 x 4 Gy in combination with hyperthermia twice weekly is a safe, effective and well tolerated method for palliative treatment of patients with dating sites for professionals with hiv cancer patients list cancer recurring in previously irradiated areas.

Девяносто семь пациентов с раком молочной железы повторяющимся в ранее облученной области средняя доза 44 Гр были вновь облучены в комбинации с гипертермией и был произведен анализ ответов опухоли. В серии повторных облучений лучевая терапия производилась два раза в неделю у большинства пациентов с различным размером опухоли доза была от hlv сГр, суммарная доза варьировалась от 8 dating sites for professionals with hiv cancer patients list 32 Гр.

Гипертермия была дана после лучевой терапии. Продолжительность ответа, в среднем, 4 месяца для lisy ответа и 26 месяцев для полного ответа, соответственно.

Медиана выживаемости для всех пациентов была 12 месяцев. Острая реакция кожи была мягкая, с более чем умеренной эритемой только у 14 из 97 пациентов.

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